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The sciatic nerve (also known as the ischiatic nerve or ischias) is a large nerve that starts in the lower back and runs through the buttock and down the lower limb. It is the longest and largest single nerve in the body. Sciatica is a set of symptoms including pain that may be caused by general compression and/or irritation of one of five nerve roots that give rise to the sciatic nerve, or by compression or irritation of the sciatic nerve itself.

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